论文部分内容阅读
目的调查深圳市人民医院真菌血症病原谱。方法收集2004-2016年深圳市人民医院真菌血症患者血液分离的真菌,使用VITEK-2、VITEK-MS系统并结合真菌内转录间隔区(ITS)测序技术进行菌种鉴定。结果 2004-2016年共发生真菌血症295例,分离296株真菌,假丝酵母菌占89.9%(266/296)。最常见前5位真菌依次为白假丝酵母菌(36.1%,107/296)、近平滑假丝酵母菌种复合群(19.3%,57/296)、热带假丝酵母菌(13.9%,41/296)、光滑假丝酵母菌种复合群(11.8%,35/296)和菌膜假丝酵母菌(4.7%,14/296);非白假丝酵母菌占53.7%(159/296)。69.8%(206/295)真菌血症来自重症医学科(ICU)(89例)、新生儿科(33例)、血液科(30例)、胃肠外科(29例)和呼吸科(25例)。结论假丝酵母菌是真菌血症最重要的病原菌,其中非白假丝酵母菌占比过半。
Objective To investigate the pathogenic spectrum of fungal encephalopathy in Shenzhen People’s Hospital. Methods The blood collected from patients with fungal sepsis in Shenzhen People’s Hospital from 2004 to 2016 was collected and identified by VITEK-2 and VITEK-MS combined with ITS sequencing. Results Fungal bacteremia occurred in 295 cases between 2004 and 2016, with 296 fungi isolated. Candida accounted for 89.9% (266/296). The most common top five fungi were Candida albicans (36.1%, 107/296), Candida parapsilosis complex (19.3%, 57/296), Candida tropicalis (13.9%, 41 / 296), Candida glabrata complex (11.8%, 35/296) and Candida albicans (4.7%, 14/296), and Candida albicans accounted for 53.7% (159/296) . 69.8% (206/295) Fungal bacteremia was from ICU (89 cases), neonatology (33 cases), hematology (30 cases), gastrointestinal surgery (29 cases) and respiratory department (25 cases) . Conclusion Candida is the most important pathogen of fungal sepsis, of which non-albicans accounted for more than half.