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探讨降钙素基因相关肽（CGRP）在小儿重症肺炎并心衰中的作用。方法采用放射免疫方法检测33例件或不件先心病重症肺炎并心衰患者血浆CGRP水平，同时测定重症肺炎治疗前动脉血氧分压。结果1．重症肺炎并心衰CGRP明显高于对照组；2.重症肺炎并降改衰CGRP与动脉血氧分压呈显著正相关；3．伴先心病肺炎患者CGRP与不伴先心病肺炎组比较无明显差异，而明显低于先心病肺炎恢复期组。结论缺氧致肺炎患者血浆CGRP下降，引起肺动脉收缩是肺炎心衰的重要机制。
To investigate the role of calcitonin gene related peptide (CGRP) in children with severe pneumonia and heart failure. Methods Radioimmunoassay was used to detect plasma CGRP levels in 33 cases with or without severe pneumonia complicated with heart failure. The partial pressure of arterial oxygen was measured before the treatment of severe pneumonia. Results 1. Severe pneumonia and heart failure CGRP was significantly higher than the control group; 2. Severe pneumonia and decreased CGRP and arterial partial pressure of oxygen was significantly positively correlated; CGRP with congenital heart disease pneumonia patients without congenital heart disease compared with no significant difference, but significantly lower than congenital pneumonia recovery group. Conclusions The plasma CGRP decreased in patients with hypoxia-induced pneumonia, leading to pulmonary artery contraction is an important mechanism of heart failure in patients with pneumonia.