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单纯疱疹病毒(HSV)是人们研究最多的一种病毒。已知有两个血清型:Ⅰ型和Ⅱ型。Ⅰ型单纯疱疹病毒(HSV-1)是人类广泛感染的病原体。世界上约有1/3的人曾受染,成人血清中抗体阳性率高达80～90%。HSV-1常引起龈口炎、唇疱疹、皮肤疱疹、角膜结合膜炎及预后险恶的急性坏死性脑炎,并有报道认为与人类的喉癌、唇癌和头颈部的鳞状上皮癌有关。原发感染后,尽管体内有较高滴度的中和抗体,病毒仍常常进入潜伏状态,一遇机会便经常诱发,呈现活跃的反复发作状态,造成一定的病害。因此对
Herpes simplex virus (HSV) is one of the most studied viruses. Two serotypes are known: type I and type II. Herpes simplex virus type 1 (HSV-1) is a pathogen of widespread human infection. About one-third of the world’s people have been infected, adult serum antibody positive rate as high as 80 to 90%. HSV-1 often causes gingival stomatitis, cold sores, skin herpes, keratoconjunctivitis, and acute necrotizing encephalitis of a malignant prognosis, and has been reported to be associated with squamous cell carcinoma of the human larynx, lip and head and neck related. After the primary infection, the virus often enters the latent state even though there is a high titer of the neutralizing antibody in the body, which is often induced by an opportunity and shows an active recurrent state and causes certain diseases. So right