论文部分内容阅读
CD4+CD25+调节性T细胞(regulatory T cells,Treg)是指一类具有免疫调节功能的T淋巴细胞,在维持机体免疫自稳、调控免疫应答方面起重要作用。近年研究表明,Treg细胞也可能通过相同的机制消弱机体的抗肿瘤效应。FOXP3是近年发现的影响Treg生物功能发挥的关键转录因子,是Treg表面特异性标志,是Treg发育和功能发挥的关键基因。综述Treg生物学特性及与肿瘤关系的研究进展。
CD4 + CD25 + regulatory T cells (Tregs) are a class of T lymphocytes with immunomodulatory functions that play an important role in maintaining immune homeostasis and regulating immune responses. Recent studies have shown that Treg cells may also be through the same mechanism to weaken the body’s anti-tumor effect. FOXP3 is a key transcription factor that has been found in recent years to affect the biological function of Tregs. It is a Treg surface-specific marker and a key gene for the development and function of Tregs. The research progress on the biological characteristics of Treg and the relationship with Tumor.