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目的:研究肥胖与2型糖尿病合并胆石症患者的血糖、胰岛素水平、血脂的关系。方法:采用病例对照研究的方法,观察45例合并胆石症的肥胖型2型糖尿病患者,体重指数(BMI)≥25,40例合并胆石症的非肥胖型2型糖尿病患者,体重指数(BMI)<25,分别分析其血脂、载脂蛋白、空腹胰岛素水平的变化及相互关系。结果:肥胖组甘油三脂(TG)、空腹胰岛素水平(FINS)较非肥胖组升高,两组间差异有显著性意义(P<0.05)。肥胖组低密度脂蛋白(LDL)较非肥胖组升高,两组间差异有显著性意义(P<0.05)。两组间胆固醇(CHOL)、高密度脂蛋白(HDL)、载脂蛋白A(ApoA)和载脂蛋白 B(ApoB)差异无显著性意义(P>0.05)。结论:2型糖尿病合并胆石症患者随体重指数升高,高胰岛素血症和血脂紊乱加重。
Objective: To study the relationship between obesity and type 2 diabetes in patients with cholelithiasis blood glucose, insulin levels, blood lipids. Methods: A case-control study was conducted in 45 obese type 2 diabetic patients with cholelithiasis. The body mass index (BMI) ≥25 and 40 non-obese type 2 diabetic patients with cholelithiasis were observed. <25, respectively, analysis of its blood lipids, apolipoprotein, fasting insulin levels and their relationship. Results: The triglyceride (TG) and fasting insulin (FINS) in obese group were significantly higher than those in non-obese group (P <0.05). Low density lipoprotein (LDL) in obesity group was higher than that in non-obesity group, the difference was significant (P <0.05). Cholesterol (CHOL), high density lipoprotein (HDL), apolipoprotein A (ApoA) and apolipoprotein B (ApoB) had no significant difference between the two groups (P> 0.05). Conclusion: Patients with type 2 diabetes mellitus and cholelithiasis have increased body mass index, hyperinsulinemia and dyslipidemia aggravate.