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目的:观察慢性肾功能衰竭患者心肌肌钙蛋白、肌酸激酶同工酶一Ⅱ的异常变化,并分析其与预后的关系。方法:应用ACCESS2化学发光法检测慢性肾功能衰竭患者心肌肌钙蛋白、肌酸激酶同工酶一Ⅱ,彩色多普勒测定左室射血分数(EF),同时对心肌肌钙蛋白升高患者进行APACHEⅡ评分。结果:48例患者血清肌钙蛋白Ⅰ升高率为44.4%;APACHEⅡ评分在心肌肌钙蛋白升高患者中明显升高;血清肌钙蛋白Ⅰ、肌酸激酶同工酶-Ⅱ同时升高患者,心衰发生率高。结论:慢性肾功能衰竭患者心肌损伤较为普遍且部分为亚临床损伤,需谨慎对待。
Objective: To observe the abnormal changes of cardiac troponin and creatine kinase isoenzyme Ⅱ in patients with chronic renal failure and to analyze its relationship with prognosis. Methods: The levels of cardiac troponin, creatine kinase isoenzyme Ⅱ, and left ventricular ejection fraction (EF) were measured by ACCESS2 chemiluminescence assay in patients with chronic renal failure. The patients with elevated cardiac troponin APACHE Ⅱ score. Results: The serum troponin I increased rate was 44.4% in 48 patients; APACHE Ⅱ score was significantly increased in patients with elevated cardiac troponin; Serum cardiac troponin Ⅰ and creatine kinase isoenzyme-Ⅱ elevated in patients , High incidence of heart failure. Conclusions: Myocardial injury is more common in patients with chronic renal failure and is partly subclinical and requires caution.