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目的探讨颅脑损伤患者血清TNF-α和IL-1β的变化及其与颅内压的关系。方法将125例颅脑损伤患者分为中度损伤组(n=45)和重度损伤组(n=80)。动态监测两组患者颅内压变化7d,同时测定颅脑损伤后1、3、7d血清TNF-α和IL-1β水平。结果重度损伤组手术后各时点血清TNF-α、IL-1β和颅内压水平均明显高于中度损伤组,差异均有统计学意义(均P<0.01)。中度损伤组患者颅内压与TNF-α呈显著正相关(r=0.986,P<0.05),与IL-1β亦呈显著正相关(r=0.979,P<0.01);重度损伤组患者颅内压与TNF-α呈显著正相关(r=0.989,P<0.01),与IL-1β亦呈显著正相关(r=0.983,P<0.01)。结论颅脑损伤患者血清中TNF-α和IL-1β水平明显增高,一定程度上可反映病情严重程度和颅内压的变化。
Objective To investigate the changes of serum TNF-α and IL-1β in patients with craniocerebral injury and its relationship with intracranial pressure. Methods 125 patients with craniocerebral injury were divided into moderate injury group (n = 45) and severe injury group (n = 80). The changes of intracranial pressure were dynamically monitored in the two groups for 7 days, and the levels of TNF-α and IL-1β in serum were detected at 1, 3 and 7 days after traumatic brain injury. Results Serum levels of TNF-α, IL-1β and intracranial pressure were significantly higher in severe injury group than those in moderate injury group (all P <0.01). There was a significant positive correlation between intracranial pressure and TNF-α (r = 0.986, P <0.05) and IL-1β (r = 0.979, P <0.01) in patients with moderate injury. There was a significant positive correlation between internal pressure and TNF-α (r = 0.989, P <0.01) and IL-1β (r = 0.983, P <0.01). Conclusion Serum levels of TNF-α and IL-1β are significantly increased in patients with craniocerebral injury, to a certain extent, it can reflect the severity of illness and changes of intracranial pressure.