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目的 研究急性心肌梗死患者急诊介入术中冠脉内应用替罗非班的近期疗效.方法 资料随机选取2016年4月—2017年4月本院诊治的急性心肌梗死患者128例, 按照不同用药方式分成两组, 对照组64例患者在静脉内使用替罗非班治疗, 研究组64例患者在冠脉内使用替罗非班治疗, 观察并比较两组患者术后心脏指标以及替罗非班用药前后冠脉灌注改善情况, 不良事件发生率.结果 两组患者术后心脏指标即LEVF、HR、BP等组间比较, 未见显著差别 (P＞0.05);两组患者经替罗非班用药治疗后冠脉灌注情况均较用药前发生不同程度的改善, 组内比较差异均具统计学意义 (P＜0.05, P＜0.01), 而用药后组间比较, 研究组TFG、MBG指标改善情况优于对照组, 差异均具统计学意义 (P＜0.05);研究组患者不良事件总发生率4.69％略低于对照组10.94％, 但组间比较未见显著差别 (P＞0.05) .结论 急性心肌梗死患者急诊介入术中冠脉内应用替罗非班的近期疗效显著, 可有效改善患者冠脉灌注情况, 且未见严重不良事件发生, 患者耐受性较佳, 具有临床实际应用价值.“,”Objective To study the short-term effect of Tirofiban's application in coronary artery for emergency intervention of patients with acute myocardial infarction. Methods The data were randomly selected from 128 cases of patients with acute myocardial infarction in our hospital from April 2016 to April 2017 for diagnosis and treatment, which, according to the ways of medication were divided into two groups. The 64 patients in control group were treated with intravenous Tirofiban, whereas the 64 patients in the study group were given arterious Tirofiban for treatment. The postoperative cardiac index, improvement of coronary artery instillation before and after medication, and the incidence of adverse events of two groups of patients were observed and compared. Results The postoperative cardiac indexes, namely LEVF, HR and BP of two groups of patients, under comparison showed no statistically significant difference (P＞0. 05). Both groups' coronary artery instillation after medication was improved to some degree than before the medication of Tirofiban, and the intra-group comparative difference was statistically significant (P＜ 0. 05, P＜ 0. 01). After medication, the improvement on TFG and MBG of the study group was better than the control group, the difference being statistically significant (P＜ 0. 05). The total incidence of adverse events in the study group was 4. 69％, slightly lower than that of the control group, which was 10. 94％, yet without significant difference between (P＞ 0. 05).Conclusion The Tirofiban's application in coronary artery for emergency intervention of patients with acute myocardial infarction in patients with acute myocardial infarction is of distinct short-term effect, which can effectively improve the patients with coronary artery instillation yet produce no serious adverse events. Moreover, patients showed better tolerability under this method. Thus, it is of clinical application value.