目的探讨抗血小板联合治疗对老年进展性脑梗死患者神经功能及日常生活能力的影响。方法纳入北京老年医院2015年9月至2016年2月收治的43例进展性脑梗死患者为研究对象,在纠正原发病、对症治疗的基础上采用抗血小板联合治疗。选取同期收治的40例进展性脑梗死的患者为对照组,采用单药抗血小板治疗。对两组治疗前后的神经功能、生活能力进行评价,并测定凝血功能指标,比较症状进展、复发率以及不良反应的情况。结果观察组治疗后的FIB小于对照组,APTT、PT大于对照组,差异有统计学意义(P<0.05)。观察组治疗后与对照组在NIHSS评分、MBI评分方面的差异有统计学意义(P<0.05)。观察组与对照组在症状进展、复发率方面的差异有统计学意义(P<0.05)。两组治疗过程中均未见严重不良反应,观察组的不良反应与对照组的差异无统计学意义(P>0.05)。结论抗血小板联合治疗老年进展性脑梗死能够显著改善患者的神经功能和生活能力,延缓症状的进展,降低复发率,且安全可靠,值得推广。 Objective To investigate the effect of antiplatelet therapy on the neurological function and daily living ability of elderly patients with progressive cerebral infarction. Methods A total of 43 patients with progressive cerebral infarction admitted to Beijing Geriatric Hospital from September 2015 to February 2016 were enrolled in this study. Antiplatelet combined therapy was used to correct primary disease and symptomatic treatment. Forty patients with progressive cerebral infarction who were treated at the same period were selected as control group and treated with antiplatelet drugs alone. Before and after treatment of the two groups of neurological function, ability to assess, and determination of coagulation function, compare the progress of symptoms, recurrence rate and adverse reactions. Results The FIB in the observation group was smaller than that in the control group, and the APTT and PT were greater than those in the control group. The difference was statistically significant (P <0.05). There was significant difference in the NIHSS score and MBI score between the observation group and the control group after treatment (P <0.05). The differences between the observation group and the control group in symptom progression and recurrence rate were statistically significant (P <0.05). No adverse reactions were observed in the two groups during the course of treatment, and there was no significant difference between the adverse reactions in the observation group and the control group (P> 0.05). Conclusion Antiplatelet therapy in elderly patients with advanced cerebral infarction can significantly improve the patient’s neurological function and life, delay the progression of symptoms, reduce the recurrence rate, and safe and reliable, it is worth promoting.