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目的:观察冠脉血栓形成的中医体质特点,为早期防治冠脉血栓形成提供临床依据。方法:将冠脉造影明确为冠心病的患者根据造影结果分为2组。冠脉血栓形成组32例,无冠脉血栓形成组68例。观察2组体质分布特点、冠脉病变积分及血栓素B2(TXB2)、血管性血友病因子(vWF)。结果:冠脉血栓形成组以瘀血质、痰湿质多见,而无冠脉血栓形成组以气虚质、气郁质、阴虚质多见(P<0.01);冠脉病变积分在瘀血质、痰湿质、气虚质、气郁质、阴虚质中存在明显差异,瘀血质>痰湿质>气虚质、气郁质、阴虚质(P<0.01)。TXB2、vWF比较,瘀血质>痰湿质>气虚质、气郁质、阴虚质(P<0.05,P<0.01)。结论:冠脉血栓形成的体质以痰湿质、瘀血质多见,痰湿质、瘀血质之人易处于高凝状态,容易形成血栓。
Objective: To observe the TCM constitution of coronary thrombosis and provide the clinical evidence for prevention and treatment of coronary thrombosis in the early stage. Methods: Coronary angiography was defined as coronary heart disease patients according to angiography results were divided into two groups. 32 cases of coronary thrombosis, coronary artery thrombosis in 68 cases. The physical distribution, coronary artery disease score, thromboxane B2 (TXB2) and von Willebrand factor (vWF) in the two groups were observed. Results: The coronary blood clot formation group was more common with stasis and phlegm-dampness than the coronary artery thrombosis group with qi deficiency, qi deficiency and yin deficiency (P <0.01) Blood stasis, phlegm-dampness, qi deficiency, qi deficiency, and yin deficiency were significantly different in blood stasis, phlegm-dampness, qi deficiency, qi deficiency and yin deficiency (P <0.01). TXB2 and vWF, blood stasis> phlegm-dampness> qi deficiency, qi deficiency and yin deficiency (P <0.05, P <0.01). Conclusion: The constitution of coronary thrombosis with phlegm-dampness, blood stasis more common, phlegm-dampness, blood stasis of the person prone to hypercoagulable state, easy to form thrombus.