环氧化酶-2(COX-2)是前列腺素合成过程中的一种限速酶,参与多种疾病的发病过程,与肿瘤的发生发展和浸润转移密切相关。许多研究表明:COX-2在胃肠道间质瘤中过量表达,主要参与胃肠道间质瘤的血管形成、改变黏附因子活性、促使肿瘤转移、抑制凋亡、抑制肿瘤免疫等。因此,提示COX-2可作为胃肠道间质瘤防治的新靶点,抑制COX-2可有效抑 Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin synthesis and is involved in the pathogenesis of various diseases. It is closely related to tumorigenesis and invasion and metastasis. Many studies have shown that: COX-2 overexpression in gastrointestinal stromal tumors, mainly involved in the formation of gastrointestinal stromal tumors, changes in adhesion factor activity, promote tumor metastasis, inhibition of apoptosis, inhibition of tumor immunity. Therefore, suggesting that COX-2 can be used as a new target of prevention and treatment of gastrointestinal stromal tumors, inhibition of COX-2 is effective