Objective:The aim of our study was to investigate the immune status of patients with rectal cancer and its relationship with clinicopathological features.Methods:The serum levels of interleukin-8(IL-8),tumor necrosis factor(TNF-α) and T-cell subgroup contents were measured using a double-antibody sandwich assay of ELISA in 43 patients with rectal cancer,and compared with the normal health adults.Results:In patients with rectal cancer,the serum levels of CD4,CD4/CD8 of T-cell subgroup in peripheral blood were significantly lower than the control group(P < 0.01),which gradually decreased with increase of Dukes stage;but the levels of CD8,IL-8 and TNF-α were higher than the control group,which gradually increased with increase of Dukes stage.Conclusion:The immunocompromice exists in patients with rectal cancer,there is a correlation between the contents of T-cell subgroup,IL-8 and TNF-α in serum and the Dukes stage of rectal cancer.Therefore immunotherapy can be used in patients with rectal cancer. Objective: The aim of our study was to investigate the immune status of patients with rectal cancer and its relationship with clinicopathological features. Methods: The serum levels of interleukin-8 (IL-8), tumor necrosis factor (TNF-α) and T -cell subgroup contents were measured using a double-antibody sandwich assay of ELISA in 43 patients with rectal cancer, and compared with the normal health adults. Results: In patients with rectal cancer, the serum levels of CD4, CD4 / CD8 of T- The cells subgroup in peripheral blood were significantly lower than the control group (P <0.01), which gradually decreased with increase of Dukes stage; but the levels of CD8, IL-8 and TNF- with increase of Dukes stage. Confluence: The immunocompromice exists in patients with rectal cancer, there is a correlation between the contents of T-cell subgroup, IL-8 and TNF-alpha in serum and the Dukes stage of rectal cancer. be used in patients with r ectal cancer.