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目的:探讨窄带成像技术(narrow band imaging,NBI)在喉癌靶向活检中的应用。方法:选取2012年8月至2014年12月在天津市人民医院耳鼻咽喉头颈外科就诊的可疑喉部恶性病变患者156例,分别行白光内镜和NBI内镜检查,记录图片资料并行病理活检,以病理组织学结果为金标准,比较白光内镜和NBI内镜在诊断喉癌上的差异。应用SPSS 16.0软件包进行统计学分析,使用χ2检验比较两组之间的差异。结果:NBI内镜能清晰显示病变范围指导靶向活检,对0期(Tis)、Ⅰ期、Ⅱ期喉癌的诊断正确率NBI内镜明显高于普通白光内镜,二者在诊断早期喉癌上的差异有统计学意义(χ2=22.00,P<0.05;χ2=8.33,P<0.05;χ2=4.55,P<0.05)。结论:在喉癌的诊断上NBI内镜能够区分黏膜病变组织和正常组织,并显示病变范围,显著优于普通白光内镜,具有很高的临床实用价值,有望成为喉部疾病筛查的常规手段,提高喉癌的早期确诊率及治疗效果。
Objective: To investigate the application of narrow band imaging (NBI) in targeted biopsy of laryngeal carcinoma. Methods: A total of 156 patients with suspicious laryngeal malignancies were treated at Department of Otorhinolaryngology Head and Neck Surgery, Tianjin People’s Hospital between August 2012 and December 2014. The patients underwent white light endoscopy and NBI endoscopy respectively, The pathological histological results as the gold standard, compare the white endoscopy and NBI endoscopy in the diagnosis of laryngeal cancer differences. SPSS 16.0 software package was used for statistical analysis, using the χ2 test to compare the differences between the two groups. Results: NBI endoscopy can clearly show the extent of lesion guidance targeted biopsy. The diagnostic accuracy of NBI in stage 0 (Tis), stage Ⅰ and stage Ⅱ laryngeal carcinoma was significantly higher than that in ordinary white endoscopy, The difference was statistically significant (χ2 = 22.00, P <0.05; χ2 = 8.33, P <0.05; χ2 = 4.55, P <0.05). Conclusion: NBI endoscopic diagnosis of laryngeal carcinoma can distinguish mucosal lesions and normal tissues, and shows the extent of lesions, significantly better than ordinary white light endoscopy, has a high clinical value, is expected to become a laryngeal disease screening routine Means to improve the early diagnosis of laryngeal cancer rate and treatment.