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本文应用粘液组织化学方法对168例肠化生、96例异型增生和89例胃癌胃粘膜活检标本进行观察,发现87.6％的胃癌和40.6％的异型增生组织有异常粘液分泌;不全结肠型肠化生和硫酸粘液阳性肠化生在癌旁和异型增生的检出率显著地高于萎缩性胃炎组(P<0.05);伴不全结肠型肠化生和伴其它型肠化生的胃癌患者平均年龄分别为59.5岁和54.4岁、男女比为6∶1和2.25∶1.结果提示有异常粘液分泌的异型增生、伴不全结肠型化生的异型增生、不全结肠型化生的高龄男性、伴不全结肠型化生的胃良性疾病和硫酸粘液阳性肠化生宜被看作是胃癌的癌前病变,其中前三组的癌变趋向性更大.
In this paper, mucinous histochemical methods were used to observe 168 cases of intestinal metaplasia, 96 cases of dysplasia and 89 cases of gastric mucosal biopsy specimens. It was found that 87.6% of gastric cancer and 40.6% of dysplasia had abnormal mucus secretion; incomplete colonic intestinal metaplasia The incidence of positive intestinal metaplasia in raw and sucrose sulfates was significantly higher than that in the atrophic gastritis group (P<0.05); the mean of gastric cancer patients with incomplete colonic intestinal metaplasia and other intestinal metaplasia was significantly higher. The ages were 59.5 years and 54.4 years respectively, and the male to female ratios were 6:1 and 2.25:1. The results suggested that there were dysplasia with abnormal mucus secretion, dysplasia with incomplete colon metaplasia, and infertile men with colonic metaplasia. Gastric benign disease with incomplete colon metaplasia and positive intestinal metaplasia with sulfate sulphate should be considered as precancerous lesions of gastric cancer, of which the first three groups have a greater tendency toward carcinogenesis.