急性脑梗死是神经科的常见病、多发病,致残率和致死率极高[1]。在中国,脑梗死后有30%~40%的患者面临有功能障碍性后遗症[2],对生活质量影响极大。脑梗死发展过程中,自由基会导致脑组织微循环发生障碍及血脑屏障通透性增强,进而引起水肿,同时还会造成脑梗死病情的进一步恶化,神经细胞坏死以及进行性缺血损害[3]。抗氧自由基对于防止或减轻脑组织的损伤及改善预后具有重要临床意义。依达拉奉为新 Acute cerebral infarction is a common neurological department, frequently-occurring disease, high morbidity and mortality [1]. In China, 30% to 40% of patients with cerebral infarction face dysfunction sequels [2], which have a great impact on the quality of life. During the development of cerebral infarction, free radicals cause the disturbance of brain microcirculation and the increase of blood-brain barrier permeability, which in turn cause edema, and further worsen the condition of cerebral infarction, nerve cell necrosis and progressive ischemic damage [ 3]. Antioxidant free radicals for the prevention or mitigation of brain tissue damage and improve the prognosis has important clinical significance. Edaravone is new