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为探讨乳腺癌血管生成与淋巴结转移的关系，作者采用免疫组织化学方法检测了１９８４年至１９８５年手术切除的７０例原发性乳腺癌石蜡标本组织中的微血管密度（ＭＶＤ）及血管内皮生长因子（ＶＥＧＦ）表达，其中有腋淋巴结转移（ＬＮ＋）者３１例，无腋淋巴结转移（ＬＮ－）者３９例。光镜下，２００倍视野计数ＭＶＤ，４００倍视野计数ＶＥＧＦ阳性细胞。结果显示：ＬＮ＋组的ＭＶＤ及ＶＥＧＦ表达显著高于ＬＮ－组；ＭＶＤ及ＶＥＧＦ等级在ＬＮ＋组亦高于ＬＮ－组。作者认为：原发性乳腺癌组织中的ＭＶＤ及ＶＥＧＦ表达与肿瘤的转移行为密切相关，有可能作为判定肿瘤生物学行为、转移潜能及预后的指标。
To investigate the relationship between angiogenesis and lymph node metastasis in breast cancer, the authors used immunohistochemical method to detect the microvessel density (MVD) and vascular endothelial growth factor in 70 cases of primary breast cancer paraffin-embedded tissue from 1984 to 1985. (VEGF) was expressed in 31 cases with axillary lymph node metastasis (LN+) and 39 cases without axillary lymph node metastasis (LN-). Under light microscopy, MVD was counted at 200-fold visual field and VEGF-positive cells were counted at 400-fold visual field. The results showed that the expression of MVD and VEGF in the LN+ group was significantly higher than that in the LN-group; the MVD and VEGF levels were also higher in the LN+ group than in the LN-group. The authors believe that the expression of MVD and VEGF in primary breast cancer is closely related to the metastatic behavior of tumors and may be used as an indicator to determine the biological behavior, metastatic potential and prognosis of tumors.