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目的:对比传统西医方法,评价中西医结合温阳利水方剂治疗心衰患者的血浆脑钠肽水平,间接评价两组疗效。方法:选择63例充血性心力衰竭患者随机分成单纯西医组和中西医结合组,以酶联免疫吸附试验法测定入选人群血浆脑钠肽水平,观察两组疗效。结果:两组人群血浆脑钠肽水平组内比较治疗后均较治疗前有明显下降(P<0.05),两组组间比较中西医结合组血浆脑钠肽值(206.21±38.4)pg/mL明显低于单纯西医组(277.32±49.6)pg/mL(P<0.05),两组治疗后中西医结合组与西医组显效率分别为57.14%和34.29%,有效率分别为32.14%和28.57%,,总显效率分别为89.29%和62.86%,两组总显效率比较中西医结合组高于西医组(P<0.05)。结论:中西医结合温阳利水方剂对充血性心力衰竭人群有确切的治疗作用,可明显降低心力衰竭患者血浆脑钠肽水平,临床疗效好于单纯西医方法治疗。
OBJECTIVE: To compare the traditional western medicine method to evaluate the level of plasma brain natriuretic peptide in patients with heart failure treated by the combination of TCM and Western medicine and Wenyang Lishui prescription, and to evaluate the curative effect of both groups indirectly. Methods: Sixty-three patients with congestive heart failure were randomly divided into western medicine group and traditional Chinese medicine combined with Western medicine group. Serum brain natriuretic peptide levels were determined by enzyme-linked immunosorbent assay (ELISA), and the curative effect was observed. Results: The levels of plasma brain natriuretic peptide in both groups after treatment were significantly lower than those before treatment (P <0.05). The plasma levels of brain natriuretic peptide (206.21 ± 38.4) pg / mL (277.32 ± 49.6) pg / mL (P <0.05). The effective rates of Integrative Medicine Group and Western Medicine Group were 57.14% and 34.29% respectively after treatment, the effective rates were 32.14% and 28.57% The total effective rate was 89.29% and 62.86%, respectively. The total effective rate in the two groups was higher than that in the Western medicine group (P <0.05). Conclusion: Integrative Medicine Wenyangliu Recipe has an exact therapeutic effect on people with congestive heart failure, and can significantly reduce the level of plasma brain natriuretic peptide in patients with heart failure. The clinical efficacy is better than that of western medicine alone.