论文部分内容阅读
目的:观察硫普罗宁(凯西莱)联合甘草酸二铵(甘利欣)治疗药物性肝损害的临床疗效。方法:将40例药物性肝损害患者随机分为观察组和对照组各20例,分别给予硫普罗宁联合甘草酸二铵治疗和单用甘草酸二铵治疗。结果:肝功能指标恢复总有效率、γ-谷氨酰转肽酶恢复总有效率、临床症状改善率,观察组分别为90%、75%、90%,对照组分别为60%、30%、50%;两组比较,差异显著(P<0.05)。结论:硫普罗宁联合甘草酸二铵治疗药物性肝损害疗效显著,谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)恢复早,效果优于单用甘草酸二铵。
Objective: To observe the clinical efficacy of tiopronin combined with diammonium glycyrrhizinate (Gan Lixin) in the treatment of drug-induced liver damage. Methods: Forty patients with drug-induced liver injury were randomly divided into observation group and control group, 20 cases were treated with tiopronin combined with diammonium glycyrrhizinate and diammonium glycyrrhizinate alone. Results: The total effective rate of liver function recovery, the total effective rate of recovery of γ-glutamyl transpeptidase and the improvement of clinical symptoms were 90%, 75% and 90% in the observation group and 60% and 30% in the control group respectively , 50% respectively; There was significant difference between the two groups (P <0.05). CONCLUSIONS: The combination of tiopronin and diammonium glycyrrhizinate is effective in treating drug-induced liver injury. The recovery of ALT, AST, and γ-GT is earlier Diammonium glycyrrhizinate alone.