本世纪六十年代初期,化学治疗开始逐步用于治疗头颈部恶性实体性肿瘤。此后二十多年时间里,新的抗癌药物不断出现,为在临床化疗中提高疗效、减低毒性反应提供了必要的物质手段;新的给药方法,各种联合化疗方案以及化疗合并加温治疗、免疫治疗、高压氧治疗等的应用,开拓了化疗发展的前景。头颈部鳞癌的化疗、也从单纯姑息性治疗向根治性治疗方向发展,从辅助地位上升到与标准治疗,即放射治疗和/或手术治疗相接近的主要地位。随着人们对生活质量要求的提高,随着人们对恶性肿瘤本质认识的深入,已经有人认为:“头颈部癌患者生存率的提高,只能依靠对恶性肿瘤本身的治疗,即化疗”。本文仅就近年来头颈部鳞 In the early 1960s, chemotherapy began to be used gradually to treat malignant solid tumors of the head and neck. In the following twenty years, new anti-cancer drugs have emerged, providing necessary material means for improving curative effect and reducing toxic reactions in clinical chemotherapy; new methods of administration, various combination chemotherapy schemes, and combined chemotherapy and warming The application of treatment, immunotherapy, and hyperbaric oxygen therapy has opened up the prospect of chemotherapy development. The chemotherapy for head and neck squamous cell carcinomas has also progressed from a simple palliative treatment to a radical treatment, and has risen from an ancillary position to a major position close to standard treatment, namely radiation therapy and/or surgery. With the improvement of people’s quality of life requirements and the deepening of people’s understanding of the nature of malignant tumors, it has been suggested that: “The survival rate of patients with head and neck cancer can only rely on the treatment of malignant tumor itself, that is, chemotherapy.” This article only on the head and neck scales in recent years