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目的探讨了胃癌患者手术治疗前后血清Hcy、IL-8和VEGF水平的变化及临床意义。方法应用放射免疫分析法和酶联法对32例胃癌患者进行了手术治疗前后血清Hcy、IL-8、IL-18和VEGF水平检测，并与35正常健康人作比较。结果胃癌患者在手术治疗前血清Hcy、IL-8、IL-18和VEGF水平均非常显著的高于正常人组（P0.05），且血清Hcy水平与IL-8、IL-18、VEGF水平呈正相关（r=0.6204、0.6134、0.5906, P<0.01）。结论检测胃癌患者手术治疗前后血清Hcy、IL-8、IL-18和VEGF水平的变化对了解病情和疾病的诊断及预后均具有重要的临床价值。“,” Objective: to explore the clinical significance of changes of serum Hcy、IL-8、 IL-18 and VEGF levels after operation in patients with gastric cancer. Methords:serum IL-8(with RIA), serum Hcy、 IL-18、VEGF(with ElisA) levels were measured both before and after operation in 32 patients with gastric cancer and 35 controls. Results: before operation, serum Hcy、IL-8、IL-18 and VEGF levels were significantly higher than those in controls(P0.05).Conclusions: changes of serum Hcy、 IL-8、IL-18 and VEGF contents after operation might be importance of monitoring pathosis and prognosis in patients with gastric cancer clinical y.