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以苯乙醇为原料,通过成环、开环反应,合成了2-(2-氯甲基苯基)乙基苯甲酸酯(3),并改进了合成工艺。改进后的工艺条件为:水相盐酸浓度6 mol/L,n(甲醛)∶n(苯甲酰氯)∶n(氯化锌)∶n(1)=3.5∶1.03∶0.7∶1,成环、开环反应时间分别为13 h和10 h。优化条件下目标化合物收率达81.6%。目标化合物的结构经1H NMR确证。改进后的工艺降低了成本,简单可行,适合工业化生产。
The synthesis of 2- (2-chloromethylphenyl) ethyl benzoate (3) was synthesized by the ring-opening and ring-opening reaction using phenethyl alcohol as raw material, and the synthesis process was improved. The improved process conditions were as follows: aqueous hydrochloric acid concentration 6 mol / L, n (formaldehyde): n (benzoyl chloride): n (zinc chloride) , Ring-opening reaction time was 13 h and 10 h respectively. Under optimized conditions, the yield of target compound reached 81.6%. The structure of the target compound was confirmed by 1H NMR. The improved process reduces the cost, simple and feasible, suitable for industrial production.