铜绿假单胞菌(pseudomonas aeruginosa,PA)作为院内感染重要的机会性致病菌,对多种抗菌药物天然耐药,其耐药机制较为复杂,其中较为重要的机制之一就是细菌生物被膜的形成。当铜绿假单胞菌形成生物膜后,其对抗菌药物的耐药能力大为增强,造成患者死亡率升高,成为临床抗感染治疗的棘手问题。因此,积极致力于铜绿假单胞菌耐药机制与生物被膜相关性研究已成为当务之急。为提高对铜绿假单胞菌 As an opportunistic pathogen of nosocomial infection, pseudomonas aeruginosa (PA) is naturally resistant to many antimicrobial agents. Its mechanism of drug resistance is complicated. One of the more important mechanisms is bacterial biofilm form. When Pseudomonas aeruginosa biofilm formation, its resistance to antibacterial drugs greatly enhanced, resulting in increased patient mortality, a clinical anti-infection treatment of intractable problems. Therefore, active research on the relationship between drug resistance mechanism of Pseudomonas aeruginosa and biofilm has become a top priority. To raise on Pseudomonas aeruginosa