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目的观察奥沙利铂(L-OHP)联合氟尿嘧啶(5-FU)、亚叶酸钙(CF)治疗晚期结直肠癌的近期疗效和不良反应。方法采用L-OHP130mg/m2,静脉滴注,持续2h,第1天;CF200mg,静脉滴注,持续2h,第2～6天;5-FU500mg/m2,静脉滴注,持续4～6h,第2～6天。21d为1个疗程,治疗4个疗程后评价疗效。结果共治34例,CR1例,PR14例,NC12例,PD7例,总有效率44.1%,不良反应主要为轻度的外周神经毒性,轻度骨髓抑制及恶心、呕吐。结论L-OHP、5-FU和CF联合化疗治疗晚期结直肠癌疗效较好,不良反应较轻。
Objective To observe the short-term effects and adverse reactions of oxaliplatin (L-OHP) combined with 5-fluorouracil (5-FU) and calcium leucovorin (CF) in the treatment of advanced colorectal cancer. Methods: L-OHP130mg / m2, intravenous infusion for 2h, on the first day; CF200mg, intravenous drip for 2h, 2 to 6 days; 5-FU500mg / m2, intravenous drip for 4 ~ 6h, 2 ~ 6 days. 21d for a course of treatment, evaluation of 4 courses of treatment efficacy. Results A total of 34 cases were treated, CR1 cases, PR14 cases, NC12 cases and PD7 cases, the total effective rate was 44.1%. Adverse reactions were mild peripheral neurotoxicity, mild myelosuppression and nausea and vomiting. Conclusion L-OHP, 5-FU and CF combined with chemotherapy for advanced colorectal cancer have better efficacy and less adverse reactions.