作者通过体外试验探讨了钙通道阻滞剂异博定(VP)是否可影响人类免疫缺陷病毒1型(HIV-1)在淋巴细胞中的复制,以及急性HIV-1感染时[Ca~(++)]_1(细胞内Ca~(++))的变化。结果:急性感染HIV-1的CEM株淋巴细胞暴露于50～75μM的VP中6天,即出现逆转录酶(RT)活性,而对照细胞至第9天RT仍呈阴性。VP浓度越大,RT出现越早(P<0.0001),50%细胞受HIV-1感染所需时间亦愈短,VP≤10μM时则对病毒复制无影响,说明一定剂量的VP能够促进HIV- The authors investigated in vitro whether ibuprofen, a calcium channel blocker, can affect the replication of human immunodeficiency virus type 1 (HIV-1) in lymphocytes and [Ca ~ (+ +)] _1 (intracellular Ca ~ (++)) changes. RESULTS: CEM strain acutely infected with HIV-1 lymphocytes were exposed to 50-75 μM VP for 6 days, indicating reverse transcriptase (RT) activity, whereas control cells were still negative by day 9. The higher the VP concentration, the earlier the RT appeared (P <0.0001), the shorter the time required for infection of 50% of the cells by HIV-1, while the VP less than 10μM had no effect on virus replication, indicating that a certain dose of VP can promote HIV-