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本研究运用染色体显带技术对人肺腺癌细胞系PC84045进行了细胞遗传学研究。结果表明,该细胞系是一个亚三倍体,染色体众数为66,染色体数目和结构存在众多异常。多倍体细胞占19/144,C-后期核型占22/144。结构异常包括双着丝粒染色体、染色单体裂隙、染色体裂隙及染色体断片、三射体、粉碎化染色体等。还可见比染色体断片小得多的微小体。本文确定了该细胞系的7个标记染色体,涉及的主要断裂点包括3q11和3p21、1p11和1p13,12p13及7q32,并对这些断裂点在肿瘸发生中的意义进行了讨论。
In this study, the use of chromosome banding technology of human lung adenocarcinoma cell line PC84045 cytogenetic study. The results show that the cell line is a sub-triploid, chromosome number 66, there are many abnormal chromosome number and structure. Polyploid cells accounted for 19/144, C-late karyotype accounted for 22/144. Structural abnormalities include dicentric chromosomes, chromatid fissures, chromosome fissures and chromosomal fragments, triadomas, and so on. There are also microscopic bodies that are much smaller than the chromosome fragments. We identified seven marker chromosomes in this cell line, involving the major breakpoints 3q11 and 3p21, 1p11 and 1p13, 12p13 and 7q32, and discussed the significance of these breakpoints in the development of lysis.