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酚妥拉明(Phentolamine,Regitine)是α受体阻断药物之一,过去临床上主要用于外周血管痉挛性疾病、嗜铬细胞瘤的诊断。近年来有报告用于难治性心力衰竭,以及抢救高血压脑病等。但对肾功能不全患者一直被列为禁用。本例试用酚妥拉明治疗慢性肾炎高血压、尿毒症,不仅未出现不良反应,而且在降低血压、增加尿量、改善症状等方面取得了一定疗效。患者段××,男,20岁。因头昏、腰痛、尿少、颜面及双下肢浮肿40天,出现恶心、呕吐伴症状加重1天,于81年12月29日入院。 81年11月12日,患者受凉感冒咽痛。1周后出现头昏、腰痛,继之尿量减少,颜面及双下肢浮肿。11月20日测血压180/130mmHg。
Phentolamine (Phentolamine, Regitine) is one of the α-blockers and has been clinically used for the diagnosis of peripheral vasospastic diseases and pheochromocytoma. In recent years there are reports for refractory heart failure, and rescue of hypertensive encephalopathy. However, patients with renal insufficiency have been banned. This trial of phentolamine treatment of chronic nephritis hypertension, uremia, not only did not appear adverse reactions, but also in reducing blood pressure, increase urine output, improve symptoms and achieved some results. Patient × ×, male, 20 years old. Due to dizziness, back pain, oliguria, facial and lower extremity edema for 40 days, nausea, vomiting with symptoms increased 1 day, December 29, 81 admission. November 12, 81, cold sore throat. 1 week after the dizziness, low back pain, followed by decreased urine output, facial and lower extremity edema. November 20 to measure blood pressure 180 / 130mmHg.