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目的通过对人贲门肠化(CIM)及贲门癌(CA)标本进行黏蛋白(MUC1)的检测,揭示MUC1在CIM和CA发生发展中的作用及其临床意义。方法经胃镜、病理确诊的CIM 50例取其黏膜作为CIM组;取胃镜活检或手术切除经病理确诊的CA标本50例作为CA组;取正常贲门黏膜20例作为正常对照组。进行免疫组化染色观察各组标本中MUC1的表达情况,并进行组间比较。结果①CIM组MUC1的表达低于CA组(P<0.01)。②MUC1的表达与CA的淋巴结转移、病理学分期呈正相关(P<0.05)。结论 MUC1的表达变化可能与CIM和CA的发生发展密切相关,MUC1与CA的某些临床病理因素相关。监测MUC1可能为CA的诊疗预后提供参考价值。
Objective To investigate the role of MUC1 in the development of CIM and CA and its clinical significance by detecting mucin (MUC1) in human cardia (CIM) and gastric cardia (CA) specimens. Methods Fifty cases of CIM confirmed by gastroscope and pathology were selected as mucosa as CIM group. Fifty cases of pathologically confirmed CA specimens were taken as CA group by gastroscope biopsy or 20 cases of normal cardia mucosa as normal control group. Immunohistochemical staining was used to observe the expression of MUC1 in each group and compared among groups. Results ① The expression of MUC1 in CIM group was lower than that in CA group (P <0.01). ② The expression of MUC1 was positively correlated with lymph node metastasis and pathological staging of CA (P <0.05). Conclusions The expression of MUC1 may be closely related to the occurrence and development of CIM and CA. MUC1 is associated with some clinicopathological factors of CA. Monitoring MUC1 may provide a reference value for the diagnosis and treatment of CA.