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由于重新评价阻塞性黄疸(阻黄)时肾功能紊乱发病机理的需要,促进了水钠代谢,心脏活动和内分泌改变等领域的研究。已证明兔胆总管结扎后细胞外水代谢库减少。为进一步阐明该模型中导致容量消耗的机理,测定兔结扎胆总管后开始4天内的水钠摄取、水平衡、促尿钠排出以及血浆中促尿钠排泄心房肽(ANP)、后叶加压素(ADH)、醛固酮(Ald)浓度和血浆肾素活性(PRA)。实验用雄性新西兰白兔。黄疸实验组(n=20)结扎胆总管,假手术对照组(n=17)单纯解剖胆总管。剖腹后开始4天记录水和饲料摄取、尿排泄,计算水平衡。麻醉和剖腹前即刻经颈
Due to the reevaluation of the pathogenesis of renal dysfunction in obstructive jaundice (yellowing), studies in the fields of water and sodium metabolism, cardiac activity and endocrine changes have been promoted. It has been demonstrated that the extracellular water metabolism pool decreased after rabbit common bile duct ligation. To further elucidate the mechanism that led to capacity consumption in this model, water and sodium intake, water balance, natriuresis and plasma atrial natriuretic peptide (ANP) were measured within 4 days after ligation of the common bile duct in rabbits. (ADH), aldosterone (Ald), and plasma renin activity (PRA). Experimental male New Zealand white rabbits. Jaundice experimental group (n = 20) ligation of the common bile duct, sham operation control group (n = 17) simple dissection of the common bile duct. Four days after laparotomy, water and feed intake, urinary excretion, and water balance were recorded. Immediate anesthesia and caesarean section through the neck