论文部分内容阅读
作者对35例慢性阻塞性肺病患者进行了右心漂浮导管检查,并同时测定了血浆心钠素浓度。结果表明:①慢阻肺伴肺动脉高压患者血浆心钠素水平明显高于不伴有肺动脉高压患者,其x±s分别为132±74pg/ml、92±16pg/L,P<0.05;②肺动脉高压患者的血浆心钠素水平与肺动脉平均压及肺血管阻力明显相关(P均<0.01),但与右心房压相关性不明显;③运动时,不伴肺动脉高压患者及正常人心钠素水平明显升高(P值分别<0.05,<0.01),而肺动脉高压患者心钠素水平变化不大。提示心钠素可能对肺动脉高压患者的肺血液动力学起着调节作用。
The authors performed right-heart catheterization in 35 patients with chronic obstructive pulmonary disease and measured plasma atrial natriuretic peptide concentrations simultaneously. The results showed that: ①The plasma atrial natriuretic peptide levels in COPD patients with pulmonary hypertension were significantly higher than those without pulmonary hypertension patients (x ± s = 132 ± 74pg / ml, 92 ± 16pg / L, P <0.05) Plasma atrial natriuretic peptide levels were significantly correlated with mean pulmonary artery pressure and pulmonary vascular resistance (P <0.01), but not with right atrial pressure. (3) During exercise, atrial natriuretic peptide (P <0.05, <0.01 respectively), while the level of atrial natriuretic peptide in patients with pulmonary hypertension did not change much. Suggesting that atrial natriuretic peptide may play a regulatory role in the pulmonary hemodynamics of patients with pulmonary hypertension.