论文部分内容阅读
目的评价左卡尼汀治疗慢性肾小球肾炎患者的临床疗效。方法将慢性肾小球肾炎患者72例随机分为观察组和对照组各36例。对照组给予氯沙坦钾治疗,观察组在对照组治疗的基础上给予左卡尼汀治疗。治疗后比较2组临床疗效。观察2组治疗前后24h尿蛋白、血清肌酐及尿素氮水平。比较2组治疗前后的舒张压及收缩压。结果观察组总有效率为91.67%高于对照组总有效率66.67%;观察组24h尿蛋白量、血清肌酐及尿素氮较对照组下降更明显,且24h尿蛋白量、血清肌酐及尿素氮较对照组下降更明显,差异均有统计学意义(P<0.05)。治疗后2组舒张压与收缩压均较治疗前有所下降,差异均有统计学意义(P<0.05)。但2组间舒张压与收缩压比较差异无统计学意义(P>0.05)。结论左卡尼汀治疗慢性肾小球肾炎疗效显著,能有效改善肾功能。
Objective To evaluate the clinical efficacy of levocarnitine in patients with chronic glomerulonephritis. Methods 72 patients with chronic glomerulonephritis were randomly divided into observation group and control group, 36 cases each. The control group was given losartan potassium, while the observation group was treated with levocarnitine on the basis of the control group. After treatment, the clinical efficacy of two groups were compared. The levels of urinary protein, serum creatinine and blood urea nitrogen were observed 24h before and after treatment. The diastolic blood pressure and systolic blood pressure were compared between the two groups before and after treatment. Results The total effective rate in the observation group was 91.67%, which was 66.67% higher than that in the control group. The 24-hour urinary protein, serum creatinine and urea nitrogen in the observation group decreased more significantly than those in the control group, and the levels of urinary protein, serum creatinine and urea nitrogen The decline of the control group was more obvious, the differences were statistically significant (P <0.05). After treatment, the diastolic blood pressure and systolic blood pressure of the two groups decreased compared with those before treatment, the difference was statistically significant (P <0.05). However, there was no significant difference in diastolic blood pressure and systolic blood pressure between the two groups (P> 0.05). Conclusion L-carnitine treatment of chronic glomerulonephritis significant effect, can effectively improve renal function.