Tobian早就发现高血压患者肾动脉组织中的钠、水含量增高,并提出这一变化使动脉壁增厚导致血压升高。从此,电解质与高血压关系的研究重点逐步转向细胞内。1980年法国和美国二个研究小组,分别发现原发性高血压存在红细胞膜Na~+-K~+协同转运和Na~+-Li~+对向转运异常,进一步推动了原发性高血压遗传标记研究。有关细胞膜离子转运与高血压的研究,已成为八十年代高血压研究的最新进展之一,它标志了高血 Tobian has long been found in patients with hypertension in renal artery tissue of sodium, water content increased, and made this change thickening of the artery wall lead to elevated blood pressure. Since then, the relationship between electrolytes and hypertension focus on the gradual shift to the cell. 1980 France and the United States two research groups were found in patients with essential hypertension exist erythrocyte membrane Na ~ + -K ~ + co-transport and Na ~ + -Li ~ + opposite transport abnormalities, and further promote the essential hypertension Genetic marker research. Research on membrane ion transport and hypertension has become one of the most recent advances in the study of hypertension in the 1980s,