人们长期认为L-Asp通过引起肿瘤细胞内氨基酸代谢失衡,继而引起胞内蛋白质生物合成严重受损,最终细胞功能受到损害,细胞死亡。然而人们对介导L-Asp发挥作用的诸多中间环节和确切分子机制尚未完全搞清楚,国内外在此领域进行了广泛的研究,本文对近年来国际上的研究进展进行简要综述。 It has long been thought that L-Asp causes an imbalance of amino acid metabolism in tumor cells, which in turn causes severe damage to intracellular protein biosynthesis, ultimately resulting in impairment of cell function and cell death. However, many intermediaries and exact molecular mechanisms that mediate the role of L-Asp have not yet been fully understood, and extensive studies have been conducted in this area at home and abroad. In this paper, we briefly review the recent advances in international research.