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目的 :研究广西肝细胞癌 ( HCC)及慢性肝病病变组织中丙型肝炎病毒 ( HCV)感染状况。探讨 HCV感染在肝癌发病中的地位。方法 :用免疫组化 SP法 ,检查 2 0 1例病变肝组织中丙肝病毒核心区抗原 ( Hepatitis C Core Antigen,HCAg)和乙肝病毒表面抗原 ( HBs Ag) ,分析各种肝脏病变中 HCV的感染状况及其与病变程度的关系。结果 :116例 HCC和 85例慢性肝病中的 HCV感染率分别是 4 4.8%和 2 8.2 %。肝癌病例中 HCV感染 80 .8%是以与 HBV双重感染的形式存在 ,单一与HCV相关的 HCC仅占全部病例的 8.4 %。伴有 HCV感染的病例 ,癌旁肝组织中炎症较明显。结论 :HCV感染虽非 HCC的主要发病因素 ,HCV引起肝细胞损伤 ,增加肝细胞对 HBV及其它致癌因素如黄曲霉毒素的敏感性 ,加快肝癌发生进程。故控制 HCV感染 ,可能降低肝癌的发病率
Objective: To investigate the status of hepatitis C virus (HCV) infection in Guangxi Hepatocellular Carcinoma (HCC) and chronic liver disease. To investigate the status of HCV infection in the pathogenesis of liver cancer. Methods: Hepatitis C Core Antigen (HCAg) and hepatitis B virus surface antigen (HBs Ag) were detected by immunohistochemical SP method in 210 diseased liver tissues. HCV infection in various liver lesions Status and its relationship with the degree of lesion. Results: The HCV infection rates in 116 HCC cases and 85 chronic liver disease cases were 44.8% and 2.2%, respectively. Eighty-eight percent of HCV infections in HCC cases were in the form of double infection with HBV, and only a single HCV-associated HCC accounted for 8.4% of all cases. Accompanied by HCV infection in the case of paracancer liver tissue inflammation more obvious. CONCLUSION: Although HCV infection is not the main risk factor of HCC, HCV causes hepatocellular injury and increases the sensitivity of hepatocytes to HBV and other oncogenic factors such as aflatoxins, accelerating the development of hepatocellular carcinoma. Therefore, the control of HCV infection, may reduce the incidence of liver cancer