目的:探讨重组人表皮生长因子治疗儿童手足口病口腔溃疡的临床效果。方法:选择吉林省人民医院2012年4月~2013年5月收治的手足口病口腔溃疡患儿80例随机分为A组和B组各40例,对两组患儿均给予针对性治疗措施;在此基础上,B组患者溃疡面情洗后在其上喷涂人表皮生长因子,治疗1个疗程后对两组患儿的疗效进行评价。结果:治疗后B组患儿疼痛改善天数、进食改善天数和口腔溃疡愈合天数均优于A组,临床治疗总有效率明显高于A组,差异均有统计学意义(P<0.05)。结论:重组人表皮生长因子治疗儿童手足口病口腔溃疡临床症状改善明显,效果良好,值得临床借鉴。 Objective: To investigate the clinical effect of recombinant human epidermal growth factor on oral ulcer in children with hand-foot-mouth disease. Methods: Eighty children with hand-foot-mouth disease oral ulcer admitted to Jilin Provincial People’s Hospital from April 2012 to May 2013 were randomly divided into 40 cases in each of group A and group B. Children were given targeted treatment measures ; On this basis, B group of patients with ulcers face wash after spraying epidermal growth factor on it, the treatment of a course of treatment after two groups of children were evaluated. Results: After treatment, the number of days of improvement, the days of improvement and the healing days of oral ulcer in group B were better than those in group A. The total effective rate of clinical treatment in group B was significantly higher than that in group A (P <0.05). Conclusion: The clinical effect of recombinant human epidermal growth factor in the treatment of hand-foot-mouth disease in children with oral ulcer has been improved obviously and has good effect, which is worthy of clinical reference.