甲氟喹(mefloquine)又称 WR142,490,是由美国华德利特陆军研究所筛选合成的化合物,目前认为是最有前途的抗疟药。作者于1980～1981年在巴黎对30例15～58岁的疟疾患者用甲氟喹进行治疗试验。其中男性27例,女性3例。恶性疟26例,同时伴有间日疟者2例。有6例的虫株对4-氨基喹啉和周效磺胺-乙胺嘧啶有抗药 Mefloquine, also known as WR142,490, is a synthetic compound screened by the Wilder Army Research Institute and is currently considered as the most promising antimalarial drug. The authors conducted trials of mefloquine in 30 malaria patients aged 15-58 years in Paris from 1980-1981. Including 27 males and 3 females. 26 cases of falciparum malaria, accompanied by vivax malaria in 2 cases. Six insect strains were resistant to 4-aminoquinolines and psoralens-pyrimethamine