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目的:调查分析郴州市海洛因依赖者中感染乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)及肝功能状况,了解吸毒人群经血传播疾病的危险因素,为这组人群的疾病预防控制提供科学依据。方法:用酶联免疫吸附试验(ELISA)分别检测249例海洛因依赖者的血清标志物即:HBsAg、抗-HCV,同时用全自动生化分析仪检测丙氨酸氨基转移酶(ALT)。结果:249例海洛因依赖者的HBsAg阳性率为18.88%、抗-HCV阳性率为73.9%、ALT异常率为37.8%。IDU组与nIDU组进行比较抗-HCV阳性率、ALT异常率差异有显著意义或极显著意义。结论:吸毒是HBV、HCV感染的高危险因素,静脉吸毒更是导致HCV高感染率的最主要因素,同时会导致肝功能异常。
Objective: To investigate the status of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection and liver function in heroin dependent persons in Chenzhou and to understand the risk factors of blood-borne diseases among drug addicts and to provide disease prevention and control for this group of people Scientific basis. Methods: Serum markers of 249 heroin addicts including HBsAg and anti-HCV were detected by enzyme-linked immunosorbent assay (ELISA), and alanine aminotransferase (ALT) was detected by automatic biochemical analyzer. Results: The positive rate of HBsAg in 249 heroin addicts was 18.88%, the positive rate of anti-HCV was 73.9%, and the rate of abnormal ALT was 37.8%. IDU group and nIDU group compared anti-HCV positive rate, ALT abnormal rate difference was significant or extremely significant. Conclusion: Drug addiction is a high risk factor of HBV and HCV infection. Intravenous drug use is the most important factor leading to high infection rate of HCV and leads to liver dysfunction.