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目的 :探讨多药耐药相关蛋白 (MRP)和P - 170在正常人外周血单个核细胞中的表达。方法 :以免疫组化ABC法检测了 4 8例正常人外周血单个核细胞P - 170的表达和 37正常人外周血单个核细胞MRP的表达 ,并同时检测了 19例正常人外周血单个核细胞P170和MRP的表达。结果 :正常人外周血细胞P170表达为 2 .6 8%± 1.77% ;正常人外周血细胞为 1.6 9%± 1.0 1%。同时检测正常人外周血细胞P - 170和MRP表达分别为 3.5 8%± 1.89%、1.6 3%± 1.0 2 %。结论 :MRP - 170在正常人外周血细胞中有一定的表达 ,两者表达有一定的一致性。
Objective: To investigate the expression of multidrug resistance associated protein (MRP) and P - 170 in peripheral blood mononuclear cells of normal people. Methods: The expression of P - 170 in peripheral blood mononuclear cells of 48 normal individuals and the expression of MRP in 37 normal human peripheral blood mononuclear cells were detected by immunohistochemical ABC method. In addition, 19 normal human peripheral blood mononuclear cells Expression of cells P170 and MRP. Results: The expression of P170 in normal peripheral blood cells was 2.68% ± 1.77%. The normal peripheral blood cells were 1.6 9% ± 1.0 1%. Meanwhile, the P - 170 and MRP expression levels in normal human peripheral blood were 3.5 8% ± 1.89% and 1.6 3% ± 1.0 2%, respectively. Conclusion: MRP - 170 is expressed in normal human peripheral blood cells, and the expression of MRP - 170 is consistent.