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目的 探讨地塞米松治疗支气管肺发育不良（ＢＰＤ）的疗效。方法 回顾性分析地塞米松治疗前后血气指标、机械通气参数并进行比较分析，判断疗效。结果 １５ 例ＢＰＤ患儿地塞米松治疗前后血气指标无明显改变，但机械通气的条件明显改善，平均气道压（ＭＡＰ）由用药前的（１－６９±０－１８）ｋＰａ 在用药３ 天后下降至（１－４８ ±０－２１）ｋＰａ，第４ 天继续下降；吸入氧浓度（ＦｉＯ２） 由用药前的（０－４５±０－０８） 在用药３ 天后下降至（０－３４±０－０７） ，差异有显著性意义。结论 地塞米松治疗可减少ＢＰＤ 患儿对氧的依赖，减少对机械通气的需要，从而改善ＢＰＤ 患儿的肺功能，改善ＢＰＤ患儿的转归。
Objective To investigate the efficacy of dexamethasone in the treatment of bronchopulmonary dysplasia (BPD). Methods Retrospective analysis of dexamethasone before and after treatment of blood gas, mechanical ventilation parameters and comparative analysis to determine the efficacy. Results Before and after dexamethasone treatment, there was no significant change of blood gas index in 15 children with BPD, but the condition of mechanical ventilation was improved obviously. Mean airway pressure (MAP) was decreased from (1-69 ± 0-18) kPa before treatment to 3 days after treatment Decreased to (1-48 ± 0-21) kPa and continued to decrease on the 4th day. The FiO2 decreased from (0-45 ± 0-08) before treatment to 0-34 ± 0 -07), the difference was significant. Conclusion Dexamethasone treatment can reduce oxygen dependence of children with BPD and reduce the need for mechanical ventilation, thereby improving the lung function of children with BPD and improving the outcome of children with BPD.