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目的研究急性早幼粒白血病（ａｃｕｔｅｐｒｏｍｙｅｌｏｃｙｔｉｃｌｅｕｋｅｍｉａ，ＡＰＬ，Ｍ３）中复合型染色体易位与临床治疗、预后的关系。方法应用常规核型分析、荧光原位杂交和逆转录酶／聚合酶链反应，检测了３例ＡＰＬ，Ｍ３。结果发现３例均有早幼粒白血病基因－维甲酸受体α基因（ｐｒｏｍｙｅｌｏｃｙｔｉｃｌｅｕｋｅｍｉａｇｅｎｅ－ｒｅｔｉｎｏｉｃａｃｉｄｒｅｃｅｐｔｏｒαｇｅｎｅ，ＰＭＬ－ＲＡＲα）融合基因转录本；核型呈复合型易位，除有１５和１７号染色体易位外还累及了５、１１、１６、２２号多条染色体，并与临床预后有一定相关性。结论对ＡＰＬ复合型易位的检测和深入研究，对临床治疗监测和预后判断有一定指导意义
Objective To study the relationship between complex chromosomal translocation and clinical treatment and prognosis in acute promyelocytic leukemia (APL, M3). Methods Three cases of APL and M3 were detected by routine karyotype analysis, fluorescence in situ hybridization and reverse transcriptase/polymerase chain reaction. The results showed that all 3 cases had a promyelocytic leukemia gene-retinoic acid receptor alpha gene (PML-RAR alpha) fusion gene transcript; the karyotype showed a complex translocation, with the exception of chromosome 15 and 17 translocations. Several chromosomes 5, 11, 16 and 22 were also involved and were associated with clinical outcomes. Conclusion The detection and in-depth study of APL complex translocation have certain guiding significance for clinical treatment monitoring and prognosis judgment.