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目的检测具有不同性质颈动脉粥样硬化斑块的脑梗死患者的血清基质金属蛋白酶-9(MMP-9)水平,探讨颈动脉粥样硬化斑块稳定性及相关炎性标志物MMP-9水平与脑梗死的关系。方法采用彩色多普勒超声检查48例颈内动脉系统的急性脑梗死患者(CI组)颈动脉粥样硬化斑块,同时检测患者血清MMP-9水平,并与20例慢性脑供血不足患者(CCCI组)及20例体检健康者(对照组)比较;根据斑块性质将CI组分为不稳定斑块组、稳定斑块组及无斑块组3个亚组,并进行组内比较。结果脑梗死组斑块检出率、不稳定斑块率及血清MMP-9水平均明显高于慢性脑供血不足组及对照组(P<0.05);脑梗死不稳定斑块组MMP-9水平显著高于脑梗死稳定斑块组,脑梗死稳定斑块组高于脑梗死无斑块组(P<0.01)。结论颈动脉粥样硬化斑块及其稳定性与脑梗死发生有密切关系,具有不同性质颈动脉斑块的脑梗死患者的血清MMP-9水平存在差异,MMP-9可能是不稳定性粥样硬化斑块及脑梗死的一个潜在的血清标志物。
Objective To investigate the serum level of matrix metalloproteinase-9 (MMP-9) in patients with cerebral infarction with different types of carotid atherosclerosis and to investigate the relationship between the stability of carotid atherosclerosis plaque and the level of MMP-9 And cerebral infarction. Methods Forty-eight carotid atherosclerotic plaques in CI group were detected by color Doppler ultrasonography. Serum MMP-9 levels were also measured in 20 patients with chronic cerebral infarction (CI group) CCCI group) and 20 healthy people (control group). The CI group was divided into 3 subgroups: unstable plaque group, stable plaque group and no plaque group according to the nature of plaque. Results The detection rate of plaque, unstable plaque rate and serum MMP-9 level in cerebral infarction group were significantly higher than those in chronic cerebral insufficiency group and control group (P <0.05). MMP-9 level in unstable plaque group Which was significantly higher than that in the stable plaque group of cerebral infarction. The stable plaque group of cerebral infarction was higher than the non-plaque group of cerebral infarction (P <0.01). Conclusion Carotid artery atherosclerotic plaque and its stability are closely related to the occurrence of cerebral infarction. Serum MMP-9 levels are different in patients with cerebral infarction with different types of carotid plaques. MMP-9 may be unstable atherosclerosis A potential serum marker of sclerosis and cerebral infarction.