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用放射性核素标记抗肿瘤单克隆抗体（ＭｃＡＢ）一直是核药物化学组的研究重点．研究出一个制备超纯无载体１１１Ｉｎ的方法．通过双功能连接剂ＤＴＰＡ环酐将其标记于抗肿瘤ＭｃＡＢ在临床实验中获得成功．用直接标记法制备的９９Ｔｃ标ＭｃＡＢ片段在诊断胃癌方面性能优良．此外，还进行了两种标记法的方法学及Ｔｃ和Ｒｅ的配位化学研究．用加速器质谱计（ＡＭＳ）研究化学物质与ＤＮＡ的加合作用及其遗传毒性是另一个研究方向．已测定过的化学物质有烟碱、烟碱衍生物ＮＮＫ、抗蚜威等，灵敏度达到每１００亿个ＤＮＡ分子中１个加合物
Labeling anti-tumor monoclonal antibodies (McABs) with radionuclides has been the focus of research in the nuclear medicine chemistry group. A method to prepare ultra-pure carrier 111In was developed. Its labeling with anti-tumor McAB via the bifunctional linker DTPA cyclic anhydride was successful in clinical trials. 99Tc-labeled McAB fragments prepared by direct labeling showed excellent performance in the diagnosis of gastric cancer. In addition, two methodologies for labeling and the coordination chemistry of Tc and Re were also performed. The use of accelerator mass spectrometry (AMS) to study the additive effects of chemicals and DNA and their genotoxicity is another area of interest. The chemicals that have been measured include nicotine, nicotine derivatives NNK, pirimicarb, etc. with sensitivity of 1 adduct per billion DNA molecules