综述了自杀基因疗法的种类及作用机制,以及自杀基因联合疗法治疗黑色素瘤的研究现状。目前治疗黑色素瘤的自杀基因疗法主要有双自杀基因治疗、自杀基因疗法联合免疫治疗、自杀基因联合细胞因子治疗以及中药联合自杀基因治疗,中药联合自杀基因疗法治疗黑色素瘤展示着较好的应用前景。 The types and mechanism of suicide gene therapy and the research status of suicide gene combination therapy for melanoma were reviewed. At present, suicide gene therapy for melanoma mainly includes double suicide gene therapy, suicide gene therapy combined with immunotherapy, suicide gene combined with cytokine therapy and traditional Chinese medicine combined with suicide gene therapy. Combined Chinese medicine and suicide gene therapy for melanoma shows a good application prospect .