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目的探讨氟伐他汀对慢性心力衰竭患者心功能及血浆脑钠肽(BNP)的影响。方法将2009年2月-2011年8月期间我科收治的94例慢性心力衰竭患者随机分为两组各47例,观察组接受常规治疗以及氟伐他汀;对照组仅接受常规治疗。结果①观察组治疗效果显著优于对照组(P<0.05)。②观察组组治疗前后BNP、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)的降低幅度显著大于对照组,左室射血分数(LVEF)的升高幅度显著大于对照组(P<0.05)。结论在常规治疗基础上联合氟伐他汀可以改善患者的心功能以及降低其血浆脑钠肽水平。
Objective To investigate the effect of fluvastatin on cardiac function and plasma brain natriuretic peptide (BNP) in patients with chronic heart failure. Methods 94 patients with chronic heart failure admitted in our department from February 2009 to August 2011 were randomly divided into two groups (n = 47). The observation group received conventional therapy and fluvastatin. The control group received routine treatment only. Results ① The observation group was significantly better than the control group (P <0.05). ② The decrease of BNP, LVEDD and LVESD in the observation group before and after treatment were significantly greater than those in the control group, and the increase of LVEF was significantly greater in the observation group than in the control group P <0.05). Conclusion The combination of fluvastatin with conventional therapy can improve the cardiac function and reduce the level of plasma brain natriuretic peptide.