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目的观察丹参水提物(SME)对心肌缺血-再灌注损伤(I/R)大鼠血流动力学的影响,探讨其对I/R大鼠心肌梗死的保护作用。方法采用SD♂大鼠左冠状动脉前降支结扎法制备I/R大鼠模型,同时给予不同剂量的SME(29.76、59.52 mg·kg-1)和复方丹参片(FDT,1.21 g·kg-1),3 d后测定心电图,记录再灌注2 h后的心率(HR)、动脉血压(MABP)、左室舒张末期内压(LVEDP)、左室收缩内压(LVSP)、左室内压最大上升/下降速率(LVdp/dtmax);计算心脏组织的梗死范围。结果29.76、59.52 mg·kg-1SME和1.21 g·kg-1FDT可使LVEDP降低,MABP、LVdp/dtmax和LVSP升高,心肌组织的梗死面积缩小;59.52 mg·kg-1SME较1.21 mg·kg-1FDT可明显改善各项指标。结论 SME对大鼠I/R具有保护作用。
Objective To observe the effect of aqueous extract of Radix Salviae Miltiorrhizae on the hemodynamics of myocardial ischemia-reperfusion injury in rats and to explore its protective effect on myocardial infarction in I / R rats. Methods I / R rat model was established by ligation of left anterior descending coronary artery in SD rats, and different doses of SME (29.76, 59.52 mg · kg-1) and Fufang Danshen tablets (FDT, 1.21 g · kg- 1). The electrocardiogram was measured 3 days later and the heart rate (HR), arterial pressure (MABP), left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP) and left ventricular pressure Rise / Fall Rate (LVdp / dtmax); Calculate infarct size of heart tissue. Results 29.76,59.52 mg · kg-1SME and 1.21 g · kg-1FDT decreased the LVEDP, MABP, LVdp / dtmax and LVSP, and the myocardial infarct size decreased. The mean value of 59.52 mg · kg-1SME was 1.21 mg · kg- 1FDT can significantly improve the indicators. Conclusion SME has a protective effect on rat I / R.