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目的:评估0、1、2号片、复方左炔诺孕酮单相片和复方左炔诺孕酮三相片的有效性、常见副反应和续用率。方法:见“我国常用口服避孕药和宫内节育器系统评估的方法概述”(中国计划生育学杂志2005年1期17页)。结果:共检索到10篇相关文献,4篇入选。在比较1号片、复方左炔诺孕酮单相片和复方左炔诺孕酮三相片的随机对照临床试验中,3组6个月累计妊娠率均小于1.1每百妇女,6个月累计续用率均大于80每百妇女,且3组相似。复方左炔诺孕酮三相片点滴出血、月经延长和缩短发生率均低于1号片,其它常见副反应发生率三者相似。在一项0号片的现况调查中,妊娠的发生率为0,突破性出血达16%以上。未检索到有关2号片有效性和续用率的文献。结论:1号片、复方左炔诺孕酮单相片和复方左炔诺孕酮三相片的有效性及续用率相近;1号片的常见副反应发生率高于复方左炔诺孕酮三相片。现有的资料不足以对0、2号片的有效性和续用率进行系统评估。
OBJECTIVES: To evaluate the efficacy, common side effects, and the rate of multiple side effects of levonorgestrel alone and levonorgestrel in patients with 0, 1, 2 tablets. Methods: See “China’s commonly used methods of oral contraceptives and IUD assessment system” (Chinese Journal of Family Planning 2005 1 period 17 pages). Results: A total of 10 related articles were retrieved and 4 were selected. In a randomized controlled clinical trial comparing 1, levonorgestrel and levonorgestrel trimesters, the cumulative 6-month pregnancy rates in 3 groups were less than 1.1 per 100 women for 6 months Rates are greater than 80 per 100 women, and 3 groups are similar. Compound levonorgestrel three-spot drip bleeding, menstrual extension and shortening the incidence were lower than on the 1st slice, the incidence of other common side effects were similar. In a 0 status survey, the incidence of pregnancy was 0, breakthrough bleeding up to 16%. No literature on the validity and reutilization rate of No. 2 was retrieved. CONCLUSION: The efficacy and the recovery rate of levonorgestrel single-phase compound and levonorgestrel three-phase tablets are similar. The incidence of common side effects of No.1 tablet is higher than that of compound levonorgestrel three photo. The available information is not sufficient to systematically assess the validity and renewal rate of No. 0 and No. 2 tablets.