论文部分内容阅读
目前已知,多发性骨髓瘤(MM)和原发性巨球蛋白血症(Waldenstrom病)属于淋巴浆细胞增生性异常,这些异常构成一组疾患,临床称之为单株峰丙种球蛋白病(monoclonal gammapathies),列为恶性的范畴。但意义未明的单株峰丙种球蛋白病(monoclonal gammapathy of undetermined significance,MGUS)其特点为体内一种单克隆浆细胞增殖,且产生一种同源性单株峰蛋白(M蛋白),临床并无MM、巨球蛋白血症以及其它有关疾病的证据。本病可保持稳定而无症状许多年,且不需治疗,有人称其为“良性丙种球蛋白病”。认识
It is known that multiple myeloma (MM) and primary macroglobulinemia (Waldenstrom’s disease) belong to the abnormality of lymphoproliferative cell proliferative disorders. These abnormalities constitute a group of disorders, which are clinically referred to as individual peak gammopathy (monoclonal gammapathies), as a vicious category. However, the unknown monoclonal gammapathy of undetermined significance (MGUS) is characterized by the proliferation of a monoclonal plasma cell in vivo and the production of a homologous single peak protein (M protein) that is clinically and / No MM, macroglobulinemia, and other evidence of the disease. The disease can remain stable and asymptomatic for many years, and without treatment, some people call it “benign gammopathy.” understanding