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测定ＩＤＤＭ患者１６例、ＮＩＤＤＭ患者２０例和正常对照组２７例的外周血单个核细胞产生白细胞介素２（ＩＬ－２）和白细胞介素６（ＩＬ－６）的能力。结果：ＩＤＤＭ患者ＩＬ－２水平较正常对照组和ＮＩＤＤＭ患者显著降低（ｐ＜０．００１），ＩＬ－６的水平显著升高（Ｐ＜０．００１）。ＮＩＤＤＭ患者ＩＬ－２和ＩＬ－６与正常对照组差异无显著性。提示ＩＤＤＭ患者ＩＬ－２和ＩＬ－６异常改变导致免疫功能紊乱。
Peripheral blood mononuclear cells (IL-2) and interleukin 6 (IL-6) were measured in 16 patients with IDDM, 20 patients with NIDDM and 27 normal controls. Results: The level of IL-2 in IDDM patients was significantly lower than that in normal controls and NIDDM patients (p <0.001), and the level of IL-6 was significantly increased (P <0.001). There was no significant difference between IL-2 and IL-6 in patients with NIDDM and normal controls. Tip IDDM patients with abnormal changes of IL-2 and IL-6 lead to immune dysfunction.