以聚合酶链反应(PCR)诊断两例胎儿胎盘水痘带状疱疹病毒感染。一例17岁初孕妇,孕4～5周时感染带状疱疹,孕19周时咨询其胎儿感染的可能性。超声检查未显胎儿异常,绒毛和羊水的病毒培养为阴性。但绒毛PCR阳性,于孕23周选择终止妊娠。胎儿活检未获明确结果,也未获得脐血水痘带状疱疹病毒IgM。胎儿脑组织的Southern印迹法同样未见带状疱疹病毒特异的基因物质。 Two cases of fetal plaque varicella zoster virus infection were diagnosed by polymerase chain reaction (PCR). A case of early 17-year-old pregnant women infected with herpes zoster at 4 to 5 weeks of pregnancy, the possibility of fetal infection in 19 weeks pregnant. Ultrasonography showed no fetal abnormalities, villi and amniotic fluid cultures were negative. However, PCR-positive villi, at 23 weeks of pregnancy choose to terminate the pregnancy. Fetal biopsy did not have a clear result, nor cord blood varicella zoster virus IgM. Southern blotting of fetal brain tissue also showed no herpes zoster virus-specific genetic material.