论文部分内容阅读
目的:探讨不同控制性超排卵方案中卵泡发育不同步的情况。方法:回顾性分析行IVF/ICSI助孕的不孕症患者1166个周期。按COH方案的不同,分为长方案组(n=1085)、短方案组(n=34)和超长方案组(n=47);另长方案组中再按年龄分为<30岁组(n=429)、30～34岁组(n=421)和≥35岁组(n=235)。将阴道B超监测最大卵泡与次大卵泡相差3mm视为卵泡发育不同步。分析启动Gn日、启动Gn后4d、7d和9d的卵泡发育不同步情况。结果:①启动Gn日卵泡发育不同步率不同COH方案组间无统计学差异;启动Gn4d、7d、9d卵泡发育不同步率短方案组最高,其次为超长方案组,最后为长方案组,但是仅在启动Gn7d时长方案与短方案比较有统计学差异(P<0.05)。②长方案组中不同年龄组比较,启动Gn日卵泡发育不同步率3组间无统计学差异。启动Gn4d、7d、9d卵泡发育不同步率随着年龄的增长而增高,但仅在启动Gn7d时<30岁组与≥35岁组间和启动Gn9d时≥35岁组与另2组间比较有统计学差异(P<0.05)。结论:①长方案较短方案和超长方案卵泡发育更同步;②随着年龄增长卵泡发育不同步逐渐增加。
Objective: To investigate the different stages of follicular development in different controlled ovarian hyperstimulation programs. Methods: A retrospective analysis of IVF / ICSI fertilization of infertility patients 1166 cycles. According to the COH program, the patients were divided into long-term group (n = 1085), short-term group (n = 34) and long-term group (n = 47) (n = 429), 30 to 34 years old (n = 421) and ≥35 years old (n = 235). The vagina B-monitoring the largest follicle and the second largest follicle difference of 3mm as follicular development is not synchronized. Analysis of starting Gn day, start Gn 4d, 7d and 9d after follicular development out of sync. Results: (1) There was no significant difference in the rate of follicular development among different COH regimens at the start of Gn follicles. The number of follicles at the start of Gn4d, 7d and 9d was the highest among the short regimen groups, followed by the extra long regimen group and the longer regimen group, However, there was a significant difference (P <0.05) between the long-term and short-term plans of Gn7d alone. ② In the long-term plan group, there was no significant difference among the three age groups in initiating Gn-day follicular development without synchronization among different age groups. At the start of Gn4d, 7d, 9d follicular development asynchronous rate increased with age, but only in the start Gn7d <30 years old group and ≥ 35 years old group and start Gn9d ≥ 35 years old group compared with the other two groups Statistical difference (P <0.05). Conclusion: (1) The longer regimen and the longer regimen follicle development are more synchronous; (2) The follicle development gradually increases with age.