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目的 评价血清肌钙蛋白I(cTnI)定量检测对不稳定型心绞痛患者 (UAP)近期预后判断的价值。方法 用化学发光酶联免疫仪对 6 2例UAP患者 ,30例健康人分别进行了血清cTnI、肌酸磷酸激酶 (CK)及肌酸磷酸激酶同功酶 (CK MB)的检测 ,并观察UAP患者住院期间的心脏事件发生率。结果 6 2例UPA患者中有 2 3例 (37.1 % )血清cTnI呈阳性 (cTnI>0 .1 μg/L) ,39例血清cTnI呈阴性 (cTnI<0 .1 μg/L) ,两组CK、CK MB水平差异无统计学意义。UAP患者cTnI阳性组 30天内发生急性心肌梗死、心源性死亡、顽固性心绞痛明显高于cTnI阴性组。结论 cTnI是反映心肌细胞损伤的高灵敏、高特异生化指标 ,cTnI水平的升高对判断不稳定型心绞痛患者近期预后有较好的预测价值。
Objective To evaluate the value of serum cTnI in the prognosis of patients with unstable angina pectoris (UAP). Methods Serum cTnI, creatine phosphokinase (CK) and creatine phosphokinase isoenzyme (CK MB) were detected by chemiluminescence ELISA in 62 UAP patients and 30 healthy individuals. The levels of UAP The incidence of cardiac events during hospitalization. Results Serum cTnI was positive (cTnI> 0. 1 μg / L) in 23 out of 62 UPA patients (37.1%) and cTnI was negative in 39 patients (cTnI <0.1 μg / L) , CK MB level difference was not statistically significant. UAP patients cTnI positive group within 30 days of acute myocardial infarction, cardiac death, refractory angina was significantly higher than cTnI negative group. Conclusion cTnI is a highly sensitive and highly specific biochemical indicator of cardiomyocyte injury. The increased cTnI level has a good predictive value in judging the short-term prognosis of patients with unstable angina pectoris.